When injected into rats’ hearts after a simulated heart attack, the drug-embedded "microparticles" reduce inflammation and scarring, the researchers found. Injecting the particles could cut the area of scar tissue formed after the heart attack in half and boost the ability of the heart to pump blood by 10 percent weeks later. Doctors believe that certain anti-inflammatory drugs, if delivered directly into the heart after a heart attack, could prevent permanent damage and reduce the probability of heart failure later in life. Fulfilling this idea — getting cheap celebrex to the right place at the right time — is more challenging than simply swallowing an aspirin, says senior author Michael Davis, PhD, assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. "If you look at previous studies to see what it would take to get enough of these drugs into the heart, they did things like direct injections twice a day," he says. "And there are clear toxicity issues if the whole body is exposed to the drug."
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Drug
New drug in the treatment of Erectile dysfunction.
Italian scientists managed to obtain a new substance that became a worthy competitor to Viagra. The substance was obtained from the plant called barrentwort (Epimedium breviornum). Some investigations showed that the plant is able to successfully restore erectile dysfunction. New substance, received from the plant possesses a wide range of benefits. Along with its high effectiveness, extract from the barrentwor lacks side effects and contradictions.
The leafs of Epimedium breviornum contains the substance called icariin. Icariin is a flavonoid glycoside that is similar in pharmacological action with sildenafil(active ingredient of Viagra).
However, it is less effective.
Italian researchers managed to overcame this disadvantage due to modifying its molecule. New molecule of icariin possesses an identical efficacy with sildenafil, being more safe and tolerable. Why? Sildenafil in Viagra can cause a number of side effects, affecting cardiovascular system and vision. Icariin is deprived of these manifestations.
These investigations can make happy Viagra "fans". However, the modified icariin should undergo many laboratory and clinical studies before it will appear on the pharmaceutical market. Ten or more years will pass before the new medication will be available.
Meanwhile the scientists may recommend to use leafs of the plant. Compared to Viagra, they are less effective, but do not possess any side effects.
